Presented by: INTRODUCTION ‘per’ means ‘through’ ‘colare’ mean ‘to strain’ Definition The process in which a comminuted drug is extracted of its soluble constituents by the slow passage of suitable solvent through a column of drug. A percolation coefficient Tf = 3.5 was determined for blends of ibuprofen and MCC. Scribd will begin operating the SlideShare business on December 1, 2020 Percolation (Exhaustive Extraction) 2.1: Process ¾Organized vegetable drug in a suitably powdered form. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Study of percolation thresholds in ternary tablets. 1. Clipping is a handy way to collect important slides you want to go back to later. ¾Packed evenly into the percolator. Calculated percolation threshold verified by testing desirable blend properties. The aim of this work is to study for the first time the existence and behaviour of the percolation thresholds in ternary pharmaceutical tablets. ¾A piece of filter paper is placed on surface followed by a layer of clean But if continuous percolation stage has … This methodology could be employed for other binary systems to predict maximum drug loading potential without the need for time consuming and expensive tablet production. Across the percolation threshold, a step change in dissolution behaviour occurred, and tablets containing air stream dried MCC showed slower disintegration rates compared to tablets containing spray dried MCC. We use cookies to help provide and enhance our service and tailor content and ads. 3. The strong solution of active constituents of drug formed during maceration is displaced by the fresh menstruum when percolation process is started. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. See our Privacy Policy and User Agreement for details. Looks like you’ve clipped this slide to already. Hassan MuJtaba It was also able to identify differences between blends containing Vivapur® or Emcocel®. Percolation theory provides a statistical model which can be used to predict the behaviour of powder blends based on particle-particle interactions. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. 43-E-14. Copyright © 2020 Elsevier B.V. or its licensors or contributors. You can change your ad preferences anytime. The application of percolation threshold theory to predict compaction behaviour of pharmaceutical powder blends. One of the handicaps for the application of the principles of percolation theory in pharmaceutical systems is the fact that this theory has been developed for binary systems. This influences the hardness of the tablet. On the other hand, the existence of a ‘combined percolation threshold’ of the sum of all the hydrophilic substances, i.e. Download : Download high-res image (562KB)Download : Download full-size image. By continuing you agree to the use of cookies. If you continue browsing the site, you agree to the use of cookies on this website. https://doi.org/10.1016/j.powtec.2019.05.027. Principal component analysis was unable to identify the threshold, but provided an overview of the changes of the analysed properties as ibuprofen drug loading increased. The percolation thresholds and the critical mass fractions were also calculated by applying a theoretical value of percolation coefficient previously published (T f =2.7) to the Eq. Now customize the name of a clipboard to store your clips. Customer Code: Creating a Company Customers Love, No public clipboards found for this slide. 12122012 “EXTRACTION with Special Reference to Maceration” Assigned by Dr. Akhtar Rasool Ph.D-Pharmaceutics Presented by Mudassar Ahmad DPH-FA11-035 “The University of Faisalabad” Modelling percolation threshold allows identification of critical drug loadings. Learn more. The model blend studied contained ibuprofen as the API, which exhibits poor flow and compressibility, and microcrystalline cellulose (MCC) as the excipient, which exhibits good flowability and compressibility. (8) . Dissolution measurements confirmed experimentally a percolation threshold in agreement with that determined using percolation theory and compression data. One of the handicaps for the application of the principles of percolation theory in pharmaceutical systems is the fact that this theory has been developed for binary systems. Calculated percolation threshold matches drug loading to form infinite cluster. This Video Lecture covers the most important pharmaceutics topics like Percolation, stage used in percolation and types of percolation. The KCl percolation threshold has been estimated in the range 0.26–0.31 of total porosity. For this purpose, mixtures containing three substances with very different … If you wish to opt out, please close your SlideShare account. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Percolation is a displacement process. This fact is in agreement with previous results. If you continue browsing the site, you agree to the use of cookies on this website. We use cookies to help provide and enhance our service and tailor content and ads. 2. See our User Agreement and Privacy Policy. Raman imaging used to visualise drug loading for formation of infinite cluster. By continuing you agree to the use of cookies. PERCOLATION Presented by: Hassan MuJtaba 43-E-14 2. This theoretical percolation coefficient was proposed for binary mixtures in which one of the substances compacts well and the second is poorly compactable, which would apply to the ibuprofen/MCC blends. "Certain pharmaceutical preparations are prepared by … Percolation 1. it helpful for Pharma graduate and diploma students . Copyright © 1996 Published by Elsevier B.V. https://doi.org/10.1016/0378-5173(96)04603-0. 11/14/16 2 COLLEGE+OF+PHARMACY UNIVERSITY+OF+BASRAH Extraction Methods for Preparing Solutions "The sole purpose of such basic extraction procedures for crude drugs are to obtained the therapeutically desirable portion and eliminate the inert material by treatment with a selective solvent known as the Menstruum. Extraction in pharmaceutics 1. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Copyright © 2020 Elsevier B.V. or its licensors or contributors. © 2019 Elsevier B.V. All rights reserved. PERCOLATION A range where PVP-CL percolates can be defined between 10 and 30% v/v. As of this date, Scribd will manage your SlideShare account and any content you may have on SlideShare, and Scribd's General Terms of Use and Privacy Policy will apply. The bulk and tapped densities of the mixtures as well as the hardness and in-vitro release behaviour of the tablets have been studied. KCl and PVP-CL, has been found at 35% v/v approximately. In conclusion, percolation theory was able to predict the maximum acceptable drug loading for this binary system of API and excipient. Blends containing 2.5 to 40% w/w of ibuprofen were compacted at a range of pressures and the values of the powder true density, compaction pressure, tablet envelope density, and tablet tensile strength were used to calculate the percolation thresholds mathematically. … It is proved that stationary menstruum (menstruum remaining in contact with the drug) dissolves more menstruum is required to exhaust the drug when simple percolation is used. Pharmaceutical preparations The process of “EXTRACTION” 2. For this purpose, mixtures containing three substances with very different hydrophilicity and water-solubility—KCl, polyvinylpyrrolidone cross-linked (PVP-CL) and Eudragit® RS-PM—were prepared and compressed. ¾Uniform moistening of the powdered vegetable drugs with menstruum for a period of 4hours in a separable vessel (Imbibition). !Percolation 2. The aim of this work is to study for the first time the existence and behaviour of the percolation thresholds in ternary pharmaceutical tablets. The drug loading threshold values predicted with the model (19.08% w/w and 17.76% w/w respectively for Vivapur® 102 and Emcocel® 90) were found to be in good agreement when compared to experimental data and the infinite cluster of drug was visually confirmed on the surface of tablets using Raman imaging. The aim of this study was to investigate if percolation theory could be used to predict the drug loading concentration of pharmaceutical tablets, and the relative density of a blend, above which tablet tensile strength is reduced, resulting in the production of unsatisfactory products. The capability of multivariate analysis to predict the drug loading threshold was also tested. Two MCC grades with differing physical properties were investigated, Vivapur® 102 (air streamed dried quality), and Emcocel® 90 (spray dried quality) to test the theory.

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